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What is Matryxl 3000 ?Matryxl 3000 - Matrixyl 3000 is comprised of 2 peptides (palmitoyl oligopeptide & palmitoyl tetrapeptide-3). The first was developed through research to find a substance that would behave similarly to Vitamin A but without the side effects. The latter works as the synergistic support ingredient to create a more optimum environment for other active ingredients to work. These peptides work together to create the most effective cell regeneration and collagen stimulator on the market. Palmitoyl Oligopeptide, (Biopeptide-CL) palmitoyl oligopeptide is derived from a protein and used as a skin conditioner and cleansing ingredient. Like Palmitoyl Pentapeptide-3, Biopeptide-CL is a synthetic protein that is a fragment of collagen combined with palmitic acid to make it more lipophillic, to improve its stability and to enhance its affinity towards human skin. As with Palmitoyl Pentapeptide-3, one could look at Biopeptide-CL as a man-made precursor to collagen. Biopeptide-CL was developed through research to identify a substance that would behave similarly to retinoic acid but without its drawbacks, especially in regards to synthesizing collagen. The reported results are as follows: In vitro: Increases collagen production by the fibroblasts by as much as 350%. Increases hyaluronic acid production by the fibroblasts by as much as 146%. In vivo: The following statistics were gathered using image analysis of volunteers who used cremes containing a 3% concentration of Biopeptide-CL for 28 days. Surface roughness --- Reduced 17% Mean depth of wrinkles --- Reduced 23% Depth of main wrinkle --- Reduced 39% Skin thickness --- Increased 4% The increase in skin thickness was considered especially notable and contrasts with the 6% reduction of the skin thickness that occurs after 10 years of aging. The study concludes to state that Biopeptide-CL is a potent active cosmetic ingredient without the adverse effects (including irritation, dehydration or long-term toxicity and instability) characteristic of retinoids. Palmitoyl Tetrapeptide-3 is a synthetic peptide that is a fragment of immunoglobulin G that has been combined with palmitic acid to make it more lipophillic and thus enhance its affinity towards human skin. Palmitoyl Tetrapeptide-3 was discovered through research to learn how to suppress the body's production of interleukins, particularly IL6, since these are the chemical messengers that trigger the body's acute inflammatory response. Inflammation is a function of immunity and is a protective response to injury or destruction of tissue. This is the body's way of walling off the injurious agent and the injured tissue. Under normal circumstances, very little IL6 is secreted and its secretion is strictly controlled. However, as we age this regulation system develops defects, and significant levels of IL6 appear in the plasma even when there is no inflammatory stimulus. This results in high levels of inflammatory proteins in the tissues and a loss of healing potential. This process has been linked with breast cancer, osteoporosis, anemia, autoimmunity and slower tissue regeneration. The hormone DHEA is directly responsible for maintaining the regulation of the production of IL6. This has even been demonstrated in the skin: when DHEA is present in sufficient amounts it is converted into a steroid hormone, androstenediol, which is directly responsible for maintain IL6 production and for maintaining local homeostasis of cytokine and interleukin production. As we age, DHEA is reduced and this directly leads to cytokine deregulation and the over-production of some interleukins and the under-production of others. As mentioned above, IL6 production is increased with negative consequences. Since UV radiation can increase IL6 production by five times, this process can significantly impact the skin. The researchers' goal thus became to find a peptide that would mimic the effects of DHEA without DHEA's potential for being converted into estrogen, since estrogen is a hormone that is not licensed for cosmetic purposes. Specifically they wanted to find a peptide that would target IL6 and inhibit its production. The results: 1. At concentrations from 10 ppm, Palmitoyl Tetrapeptide-3 induces a marked reduction in the secretion of the cytokine IL6. This reduction is progressive and depends on the concentration of the peptide: baseline secretion may be inhibited by up to 40%. 2. Palmitoyl Tetrapeptide-3 reduced levels of IL6 after cells were exposed to UV radiation by up to 86% even though IL6 had been increased by about 20 fold by the UV. These results show that Palmitoyl Tetrapeptide-3 is able to affect baseline levels of IL6 as well as modulate the effects of UV-stimulated overproduction of IL6. IL6 is marketed by Sederma as a molecule that can restore cytokine equilibrium, which characterizes youthful skin. 1-800 Patches has chosen to use Palmitoyl Tetrapeptide-3as a synergistic support ingredient to create a more optimum environment for other active ingredients to help restore youthful skin appearance.
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